|
KMID : 0361020010440050458
|
|
Korean Journal of Otolaryngology - Head and Neck Surgery
2001 Volume.44 No. 5 p.458 ~ p.465
|
|
|
Intraotic drug Delivery Following Gentamicin Infusion Using the Osmotic Pump in Chinchilla
|
|
정원호/Won Ho Chung
홍성화/Sung Hwa Hong
|
|
|
Abstract
|
|
|
Backgrounds and Objectives : We developed a method of intraotic treatment using gentamicin (GM) in chinchillas. Materials and Method : An osmotic pump, connected near the round window by a Teflon tube (0.13 mm ID ×0.18 mm OD) through an opening
in
the
scala tympani, continuously perfused 12 ㎕ of GM per day for a week. In the three experimental groups (n=12), each animal was treated with a total dose of 0.1 mg of GM for a week. Animals in the control group (n=4) were immediately sacrificed
after
perfusion with saline for a week. Results : In the control group, there was no damage in any of the hair cells. In the treatment group, the hair cells were more severely damaged at 4 weeks than at l week. The outer hair cells were more sensitive
to
GM
than the inner hair cells. Among the outer hair cells, the first rows were damaged first. The basal part of cochlea was damaged earlier than the apical. The ototoxic effect continued even after perfusion had ceased. Conclusions : This pump system
limits
drug distribution to the target tissue, minimizing systemic side effects while permitting precise control of delivery rate, volume concentration and duration.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|